Mupirocin Calcium for Skin Infections Treatment Antibiotics
Mupirocin Raw Material CAS:12650-69-0
Chemical name: Mupirocin
Appearance: White Powder
Purity: Over 99%
What is Mupirocin?
Mupirocin is an antibiotic. It is used topically and is effective
against Gram-positive bacteria, including MRSA.Mupirocin is
inactive for most anaerobic bacteria, mycobacteria, mycoplasma,
chlamydia, yeast and fungi.
Mupirocin is bacteriostatic at low concentrations and bactericidal
at high concentrations.It is of the monoxycarbolic acid
class.Mupirocin is a mixture of several pseudomonic acids, with
pseudomonic acid A (PA-A) constituting greater than 90% of the
mixture. Also present in mupirocin are pseudomonic acid B with an
additional hydroxyl group at C8,pseudomonic acid C with a double
bond between C10 and C11, instead of the epoxide of PA-A,and
pseudomonic acid D with a double bond at C4` and C5` in the
9-hydroxy-nonanoic acid portion of mupiroci
How does it work (mechanism of action)?
Unlike most other antibiotics which act on either bacterial DNA or
the walls of bacteria, mupirocin blocks the activity of an enzyme
called isoleucyl-tRNA synthetase within the bacteria. This enzyme
is necessary in order for the bacteria to make proteins. Without
the ability to make proteins, the bacteria die. Because of its
unique mechanism of action, there is little chance that bacteria
will have become resistant to mupirocin because of exposure to
It is suitable for skin infections caused by a variety of bacteria,
especially gram-positive cocci, such as pustulosis, furuncle,
folliculitis and eczema, dermatitis, various types of ulcers and
|Appearance||A white or off-white powder||Conforms|
|Specific Optical Rotation||-20°~ -16°||-18°|
|Impurity C||Not more than 2.5%||1.6%|
|Individual impurity||Not more than 1.0%||Conforms|
|Total impurities||Not more than 4.5%||3.5%|
|Chlorides||Not more than 0.5%||Conforms|
|Water||Not more than 1.0%||0.1%|
|Residual Solvents||Ethyl Acetate||Not more than 500 ppm||Not deteced|
|Isobutyl Acetate||Not more than 5000 ppm||5|
|Heptane||Not more than 500 ppm||2|
|Acetone||Not more than 3000 ppm||15|
The product of a variety of Gram-positive bacteria associated with
skin infections especially staphylococcus and streptococcus highly
sensitive to resistant Staphylococcus aureus is also effective.
Certain Gram-negative bacteria have some antibacterial effect. With
no cross-resistance to other antibiotics.
Infections of skin and soft tissue caused by Gram-positive cocci,
such as impetigo, boils, folliculitis primary infection and eczema,
dermatitis, ulcers, and other skin trauma secondary infection.
Application of Mupirocin Calcium :
Mupirocin is used as a topical treatment for bacterial skin
infections, for example, furuncle,impetigo, open wounds, etc. It is
also useful in the treatment of methicillin-resistantStaphylococcus
aureus (MRSA), which is a significant cause of death in
hospitalized patients having received systemic antibiotic therapy.
It is suggested, however, that mupirocin cannot be used for
extended periods of time, or indiscriminately, as resistance does
develop, and could, if it becomes widespread, destroy mupirocin's
value as a treatment for MRSA. It may also result in overgrowth of
Mupirocin Calcium is used to treat infected cuts or wounds. It is
an antibiotic that works by stopping the growth of certain bacteria
Safety and side effects
The incidence of adverse reactions was as follows: nausea (4.9%), headache and burning at
application site (3.6% each), pruritus (2.4%), and 1 report each of
abdominal pain, bleeding secondary to eczema, pain secondary to
eczema, hives, dry skin, and rash.
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How to start orders or make payments
A:You can send our your Purchase order(if your company has), or
send a simple confirmation by email or by Trade Manager, and we
you Proforma Invoice with our bank details for your confirmation,
can make payment accordingly.
Q: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay
cost or arrange a courier to us and take the samples. You can send
product specifications and requests,we will manufacture the
to your requests.
Q: What’s your MOQ
A:For the high value product, our MOQ starts from 1g and generally
from 1kgs. For other low price product, our MOQ starts from 10kg
Q: Is there a discount
A: Yes, for larger quantity, we alway support with better price.
Q:How do you treat quality complaint
First of all, our quality control will reduce the quality problem
to near zero.
If there is a quality problem caused by us, we will send you free
replacement or refund your loss.
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