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Carvedilol Pharma Raw Materials Antihypertensive drug CAS:72956-09-3

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Carvedilol Pharma Raw Materials Antihypertensive drug CAS:72956-09-3

Brand Name : Hongkong SaiChuang
Model Number : 616204-22-9
Certification : ISO9001
Place of Origin : China
MOQ : 10g
Price : negotiable USD
Payment Terms : Western Union, L/C, , D/A, MoneyGram, T/T, D/P
Supply Ability : 1000KG/month
Delivery Time : within 12 hours after payment
Packaging Details : safe discreet package
Origin : ZheJiang
Name : Carvedilol
WhatsApp : +86 18873303856
Email : majorina.cai@chembj.com
CAS : 72956-09-3
Tel : +86 18873303856
MF : C24H26N2O4
MW : 406.47
Purity : 99%
Appearance : White crystalline powder
Packaging : discreet packaging
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Carvedilol Pharma Raw Materials Antihypertensive drug CAS:72956-09-3


Basic INFORMATION

Product name:Carvedilol

CAS:72956-09-3

MF:C24H26N2O4

MW:406.47

Standard:EP/USP

EINECS:1308068-626-2

Melting point:113-117°C

storage temp.:Store at +4°C


What is Carvedilol​?

Carvedilol is a AR (α1 and β-adrenergic receptor) antagonist with antioxidant properties. Studies show that the receptors α1D-AR and α1B-AR have a greater affinity for Carvedilol in comparison to the receptor β1-AR subtype. Carvedilol has been observed to block the oscillatory intracellular calcium changes induced by α1D-AR and α1B-AR, and shown to have a higher oxidative effect than Atenolol (sc-204895). The S(-) enantiomer of Carvedilol acts as a β-blocker, and the R(+) and S (-) enantionmers both block the α1. Carvedilol is an inhibitor of α1B-AR, β1-AR, β2-AR and α1D-AR.

Used for?
Carvedilol is used to treat high blood pressure and heart failure. It is also used after a heart attack to improve the chance of survival if your heart is not pumping well. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
COA
ITEMSTANDARDRESULTS
AppearanceWhite or almost white crystalline powderConforms
SolubilityPractically insoluble in water, Slightly soluble in alcohol,Practically insoluble in dilute acidsConform
Identification

IR: Similar to standard

HPLC: Similar to standard

Conform
Melting point113°C-116°C114.1°C-115.8°C
Loss on drying≤0.5%0.30%
Heavy Metals≤0.001%less than 0.001%
Sulphated Ash≤0.1%0.02%
Minute granulenot more than 20umConform
Assay99.0%-101.0% of C24H26N2O4, CALCULATED ON DRIED BASIS

99.67%

Function

Carvedilol has strong heart and neuroprotective effects: unlike normal β-receptor antagonists, long-term use of this product in hypertensive patients can not only dilate coronary and renal vessels, reduce peripheral vascular resistance, but also reduce systemic circulation. And pulmonary circulation resistance, effectively control high blood pressure. This product has a protective effect on renal function, does not change renal blood flow, but reduces microalbuminuria, reduces renal vascular resistance, and has a good regulatory effect on blood lipids.


Application ofCarvedilol :


Medical Uses:

Carvedilol is indicated in the management of congestive heart failure (CHF), commonly as an

adjunct to angiotensin-converting-enzyme inhibitor (ACE inhibitors) and diuretics. It has been clinically shown to reduce mortality

and hospitalizations in people with CHF. The mechanism behind its positive effect when used long-term in clinically stable CHF patients is not fully understood, but is thought to contribute to remodeling of the heart, improving upon its structure and function.


In addition, carvedilol is indicated in the treatment of hypertension. It can be used alone or with

other antihypertensive agents. In the 2013 guideline, it is recommended as the drug of choice in

people with histories of CHF and/or myocardial infarction.

Safety and side effects

Coreg (carvedilol) is a beta-adrenergic blocking agent (beta-blocker) used to treat heart failure, hypertension, and left ventricular dysfunction after a heart attack. Coreg is available in generic form. Common side effects of Coreg include

dizziness,
lightheadedness,
drowsiness,
diarrhea,
nausea,
vomiting,
weakness,
tiredness,
headache,
joint pain,
cough,
dry eyes,
vision changes,
numbness or tingling sensation,
decreased sex drive,
impotence, or
difficulty having an orgasm.
Contact your doctor if you experience serious side effects of Coreg including

feeling faint,
slow or irregular heart beats,
chest pain,
shortness of breath,
difficulty swallowing
loss of bladder control, or
severe skin reaction.


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How to start orders or make payments

A:You can send our your Purchase order(if your company has), or just
send a simple confirmation by email or by Trade Manager, and we will send
you Proforma Invoice with our bank details for your confirmation, then you
can make payment accordingly.
Q: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping
cost or arrange a courier to us and take the samples. You can send us your
product specifications and requests,we will manufacture the products according
to your requests.
Q: What’s your MOQ
A:For the high value product, our MOQ starts from 1g and generally starts
from 1kgs. For other low price product, our MOQ starts from 10kg and 100kg.
Q: Is there a discount
A: Yes, for larger quantity, we alway support with better price.
Q:How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero.
If there is a quality problem caused by us, we will send you free goods for
replacement or refund your loss.
Q:How to contact us
A:You can choose your interested products and send inquiry to us.You can
dial our telephone directly, you will get our reply.
Our Superiority
Price
Best prices you're sure to be satisfied, the more you buy, the more competitive prices you get.
Packing
Professional packing with professional materials, and We'll give clients several Packing way to choose after you contact me through my email
Quality
Our company is a professional leading factory in China in pharmaceutical area, ach batch of steroid powders have to tested by our QC(quality control) department before they are allowed to sell.
Payment
T/T in advance, WU,Money Gram and Bitcoin
Delivery
We can pack your powders within 12 hours after your payment, and corresponding picture of your powders' parcel will be sent to you.
We are one of the leading manufacturers and exporters in China. We specialize in anabolic steroids, peptides,SARMs,fat burner and pharmaceutical intermediates. If you have any questions of our products that you are interested in, please contact as without hesitate.

Payment & Shipping Terms:

Minimum Order Quantity: 10g

Price: Negotiated

Packaging Details: Dicreet package

Delivery Time: Within 12 hours after confirming the payment

Payment Terms: T/T, Western Union, MoneyGram, Bitcoin

Supply Ability: 1000kg/Month

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